WebMD does not provide medical advice, diagnosis or treatment. My skin is oily too! Benzoyl peroxide is a tumor promoter in several animal species. It is not known if adapalene and benzoyl peroxide topical gel passes into your breast milk and if it can harm your baby. ", Epiduo Forte (adapalene / benzoyl peroxide) "After having about 10 weeks of treatment for my cystic adult acne at age 31 with a dermatologist who only prescribed doxy and no topicals with limited results, I found another dermatologist who prescribed me Epiduo forte in conjunction with my antibiotic. Adapalene and benzoyl peroxide Topical application, IGA: two-grade improvement and "clear" or "almost clear", Inflammatory lesions: mean absolute (percent) reduction, Non-inflammatory lesions: mean absolute (percent) reduction, MANUFACTURE(62332-662), ANALYSIS(62332-662). If you wish to read unlimited content, please log in or register below. Use this medication on the skin only. Adapalene / benzoyl peroxide topical has an average rating of 7.3 out of 10 from a total of 846 ratings for the treatment of Acne. All participants applied either A0.3/BPO2.5 gel or vehicle daily per half face for 24 weeks. View medicinal form and pricing information Many people using this medication do not have serious side effects. If a serious hypersensitivity reaction occurs, discontinue adapalene and benzoyl peroxide topical gel immediately and initiate appropriate therapy. What are the side effects of adapalene and benzoyl peroxide? With the Adapalene 0.3% with Benzoyl Peroxide 2.5% gel study, there was a statistically significant improvement in the scar assessment as early as Week 1. ", Epiduo (adapalene / benzoyl peroxide) "So I have been battling acne for ages, I am currently on lymecycline as well as Epiduo. topical gel, tell your doctor about all of your medical conditions, including if you: How should I use adapalene and benzoyl peroxide, What should I avoid while using adapalene and benzoyl, What are the possible side effects of adapalene and benzoyl peroxide. Recommend the use of broad spectrum sunscreen products and protective apparel (e.g., hat) when exposure cannot be avoided [see Warnings and Precautions (5.2)]. Through these I still stuck to applying epiduo gel every night and I swapped to a gentler moisturiser from cera ve. Its been over a month now and I only have some acne scars left to clear. ", Epiduo (adapalene / benzoyl peroxide) "This Epiduo was a miracle cream! The chemical name for adapalene is (6-[3-(1-adamantyl)-4-methoxyphenyl]-2 . Benzoyl peroxide is an oxidizing agent with bactericidal and keratolytic effects. topical gel may cause serious side effects including: adapalene and benzoyl peroxide topical gel, How should I store adapalene and benzoyl peroxide. Adapalene is applied in a thin layer of gel to the affected areas once daily at bedtime. Epiduo (adapalene / benzoyl peroxide) is intended to be used topically only. My heart goes out to everyone suffering from this and I hope you find that this combination works for your skin too!! I went in with a pea sized amount but used it everyday since the start. Even though my face is very very red, I can tell this gel is working and Im super excited to have the possibility of clear skin. Selected from data included with permission and copyrighted by First Databank, Inc. I had horrendously dry skin alongside the purge and no makeup would cover my skin. Keep persevering and you'll see the light. I am currently 3 months in and, again, my skin is so much worse than when I started it, constantly dry, red and full of hyperpigmentation. Adapalene and benzoyl peroxide topical gel may bleach your hair or colored fabrics. Use this medication regularly to get the most benefit from it. Prevention and reduction of atrophic acne scars with adapalene 0.3%/benzoyl peroxide 2.5% gel in subjects with moderate or severe facial acne: results of a 6-month randomized, vehicle-controlled trial using intra-individual comparison. Adverse Events: In the pivotal study, the most commonly reported adverse reactions (1%) in patients treated with Epiduo Forte Gel were skin irritation, eczema, atopic dermatitis and skin burning sensation. ", Epiduo (adapalene / benzoyl peroxide) "Epiduo has honestly been the only product which has had a significant impact on my skin. A difference is the frequency of application of the medications. Avoid eyes (apply petroleum jelly around them first). Select a condition to view a list of medication options. Cosmetics may be used, but clean skin thoroughly before applying the medication. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Adapalene and Benzoyl Peroxide Topical Gel, 0.3%/2.5%, Adapalene and Benzoyl Peroxide Gel, 0.1%/2.5%, Adapalene and Benzoyl Peroxide Topical Gel, 0.3%/2.5% (N=213), Adapalene and Benzoyl Peroxide Gel, 0.1%/2.5% (N=212), Adapalene (a dap' a leen) and Benzoyl Peroxide (BEN-zoe-il per-OX-ide), Do not use adapalene and benzoyl peroxide topical gel if you, Before using adapalene and benzoyl peroxide. I began taking epiduo about 4 months ago. Vehicle gel; The main objective of this trial was to evaluate the effect of Adapalene 0.3% - BPO 2.5% (ABPO Forte) gel versus vehicle gel on the risk of formation of atrophic acne scars in moderate to severe acne participants. Data sources include IBM Watson Micromedex (updated 1 Nov 2022), Cerner Multum (updated 25 Oct 2022), ASHP (updated 12 Oct 2022) and others. Avoid the eyes, lips and mucous membranes. Adapalene and benzoyl peroxide topical gel is indicated for the topical treatment of acne vulgaris in adults and pediatric patients 12 years of age and older. See package insert for complete prescribing information. Methods In Part 1 of this two-part study, A0.3/BPO2.5 gel or vehicle was applied on each half-face for 24 weeks in a randomized, investigator . 1 yr. ago. Yeah girls it will get worse before it gets better, dont give up. and street price at CVS of $170 (!). Inactive: acrylamide/sodium acryloyldimethyltaurate copolymer, docusate sodium, edetate disodium, glycerin, isohexadecane, poloxamer 124, polysorbate 80, propylene glycol, purified water and sorbitan oleate. The efficacy of current topical acne treatments in mitigating the potential for acne scarring is not known. The first couple of weeks my skin was dry but thats about it. It only has to be applied to the skin once a day at bedtime. When buying cosmetics, moisturizers, or other skin care products, check the label for "non-comedogenic" or "non-acnegenic." This survey is being conducted by the WebMD marketing sciences department. I used the gel every night and it made my face red and itchy but I continued on and eventually when things got better I cut down to applying it once every two days. By Dr. Yoram Harth, MD 2018-11-13. A total of 197 subjects with acne vulgaris, 12 years and older, were treated once daily for 12 weeks. It is week 10 for me and it just started to clearing up. Call your doctor if eye irritation develops. Approximately equal number of males (48%) and females (52%) were enrolled. This takes 3 months for the redness to be only visible really up close. Epiduo Forte. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Adapalene and benzoyl peroxide topical gel comes in a pump. I had read some reviews that said DON'T GIVE UP!! Adapalene and benzoyl peroxide topical gel, 0.3%/2.5% is white to very pale yellow in color and opaque in appearance, and is supplied as follows: Advise the patient to read the FDA approved patient labeling (Patient Information). The frequency of use should be decreased if excessive dryness or irritation occurs. You want as little as possible, but dont worry it will still work. So I'll let you know how it goes. Dry patches appeared around my eyes and mouth. AVOID your eyes or anywhere even near your eyes! My skin is completely clear with NO new breakouts in sight. The chemical name for adapalene is (6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid). The recoveries of adapalene and benzoyl peroxide were 93.110.78% and 95.171.02%, respectively, that fall within limits of the USP monograph. I have experienced the burning sensation throughout the process so far, however it is not major. However after about a week it became extremely painful and my skin burned like crazy. Their primary functions in this capacity are to reduce inflammation and kill bacteria, but they also have other benefits. Volume of distribution I think whats really important is using a gentle cleaner and moisturiser, not picking on the pimples, and hydrate and last but not least, let the time pass!! ", Epiduo (adapalene / benzoyl peroxide) "This is my third week of epiduo. Clindamycin Phosphate/Benzoyl Peroxide Gel Effective for Acne in Darker Skin Tones. Content titles and body; Content titles only What conditions does Adapalene-Benzoyl Peroxide Gel With Pump treat. In the US - Call your doctor for medical advice about side effects. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Subjects had an average of 98 (range 51-226) total lesions of which the mean number of inflammatory lesions was 38 (range: 20-99) and the mean number of non-inflammatory lesions was 60 (range 30-149). Erythema, scaling, dryness, and stinging/burning may be experienced with use of adapalene and benzoyl peroxide topical gel. Brand names: | Find, read and cite all the research you need on . Today I was driven to tears at the extreme pain I was feeling so Im going to have to stop using it. I was about to stop my treatment but I'm glad I kept going. Use a pea-sized amount for each area of the face (e.g., forehead, chin, each cheek). Your doctor may want you to use a moisturizer, decrease how often you use the product, or have you stop using it. Adding the Dermatologist's fee, the out of pocket cost of getting one tube of Epiduo can reach >$100. Stick with it and you will see results! No formal drug-drug interaction studies were conducted with adapalene and benzoyl peroxide topical gel. And now it's finally getting better. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Adapalene, a synthetic retinoid, is a naphthoic acid derivative with retinoid-like properties. Adapalene 0.3% gel shows efficacy for the treatment of atrophic acne scars. This medicine is available only with your doctor's prescription. for the Before using this medication, tell your doctor or pharmacist your medical history, especially of: other skin conditions (such as eczema). By week 24, a statistically significant 15.5% decrease from baseline in total scar count was reported among A0.3/BPO2.5-treated patients compared with a 14.4% increase with vehicle treatment (a difference of approximately 30%), with a mean of 9.5 scars vs 13.3 scars per half face, respectively (P <.0001). Avoid concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have strong skin-drying effect and products with high concentrations of alcohol, astringents, spices or limes). Cold weather and wind may irritate skin treated with adapalene and benzoyl peroxide topical gel. Advise breastfeeding women not to apply adapalene and benzoyl peroxide topical gel directly to the nipple and areola to avoid direct infant exposure [see Use in Specific Populations (8.2)]. Side effects of adapalene and benzoyl peroxide that are similar include skin irritation, redness, dryness, itching, flares of acne, and increased sun sensitivity. Kerrouche N, Tan J. Do not apply to the inner lip area, inside the nose/mouth, or on mucous membranes. Reduces inflammation: By killing bacteria, benzoyl peroxide may reduce inflammation inside acne lesions. first appeared they'd get big and grow white heads like a black head i recently started popping them and they'd leave scars on my lip . To evaluate the effect of adapalene 0.1%/benzoyl peroxide 2.5% (A/BPO) gel compared to vehicle in reducing the risk of acne scarring. It: Reduces bacteria: Benzoyl peroxide quickly absorbs into the skin where it kills 99.9% of bacteria almost immediately. See carton closure for lot number and expiry date. Dont give up! While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals. The benzoyl peroxide in Epiduo (adapalene / benzoyl peroxide) can bleach fabric, including clothing and bed sheets. My doctor told me to give it another few months so I stuck at it. Adapalene and benzoyl peroxide are topical agents used to treat acne vulgaris (pimples). Wash your hands before applying this medication. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. She used Aveeno moisturizer and was consistent with the Epiduo Forte use. Who should not take Adapalene-Benzoyl Peroxide Gel With Pump? Store adapalene and benzoyl peroxide topical gel at room temperature between 68F to 77F (20C to 25C). Benzoyl peroxide is a highly lipophilic oxidizing agent that localizes in both bacterial and keratinocyte cell membranes. Avoid spending time in sunlight or artificial sunlight, such as tanning beds or sunlamps. Limit your time in the sun. The 0.1% gel formulation is available over the counter, without a . To cite this article: Drno B, Layton AM, Troielli P, Rocha M, Chavda R. Adapalene/benzoyl peroxide gel 0.3%/2.5% for acne vulgaris. Prevention and reduction of atrophic acne scars with adapalene 0.3%/benzoyl peroxide 2.5% gel in subjects with moderate or severe facial acne: results of a 6-month randomized, vehicle-controlled trial using intra-individual comparison. Treatment response was defined as the percent of subjects who were rated "clear" or "almost clear' at Week 12 with at least a two-grade improvement based on the Investigator's Global Assessment (IGA), and mean absolute change from baseline at Week 12 in both inflammatory and non-inflammatory lesion counts. Epiduo (adapalene / benzoyl peroxide) "Used Epiduoyears ago after coming off of oral contraceptives. Medically reviewed by Drugs.com. Avoid applying adapalene and benzoyl peroxide topical gel to cuts, abrasions, and sunburned skin. To minimize potential exposure to the breastfed infant via breastmilk, use adapalene and benzoyl peroxide topical gel on the smallest area of skin and for the shortest duration possible while breastfeeding. Are adapalene and benzoyl peroxide safe to use while pregnant or breastfeeding? Epiduo Forte (adapalene and benzoyl peroxide) Gel, 0.3%/2.5% is a once-a-day prescription topical acne medication with two active ingredientsadapalene and benzoyl peroxide. Hence, maternal use is not expected to result in fetal exposure of the drug. My doctor prescribed epiduo and Dermaplex soap free face scrub and the first week burnt like anything. In the morning just as spot treatment. What should I know regarding pregnancy, nursing and administering Adapalene-Benzoyl Peroxide Gel With Pump to children or the elderly? An IGA score of "almost clear" corresponded to a few scattered comedones and a few small papules. Background Scarring is a frequent consequence of acne. This gel is said to penetrate the skin more effectively without drying it out. While benzoyl peroxide can help treat oil and dead skill cells that clog your pores, this may not be the best treatment option available for blackheads and whiteheads. Until I turned 28 and had horrible hormonal acne on my cheeks and jawline. Package insert / prescribing information ", Epiduo (adapalene / benzoyl peroxide) "Do not let the negative reviews stir you away from this medication! Do not apply adapalene and benzoyl peroxide topical gel directly to the nipple and the areola to minimize contact with your baby. What is Epiduo gel? Vaseline acts as a barrier and therefore the benzoyl peroxide wont travel to the affected areas. In one clinical study treating patients once per day with 2g of 0.3% gel applied to 2 mg/cm 2 of skin, 15 patients had detectable blood plasma adapalene levels (0.1 ng/ml) resulting in a mean C max of 0.553 0.466 ng/ml and a mean AUC of 8.37 8.46 ng*h/ml on day 10.. Usual dosage: Apply a thin layer once a day to affected areas. An IGA score of 'Clear' corresponded to clear skin with no inflammatory or non-inflammatory lesions. ", Epiduo (adapalene / benzoyl peroxide) "I have had acne my whole life. Background Very few clinical trials have investigated the effect of topical acne treatment on scarring. Indication: Epiduo Forte (adapalene and benzoyl peroxide) Gel, 0.3%/2.5% is indicated for the topical treatment of acne vulgaris. I appreciate all the success stories and Im glad that people have experienced positive outcomes with their skin, but the experience for me was absolutely awful.". The following adverse reactions have been identified during postapproval use of adapalene and benzoyl peroxide topical gel. The most common side effects of adapalene are: Most of these side effects lessen with continued use; however, if they are bothersome, decreasing the frequency with which adapalene is applied may reduce these side effects. The topical gel adapalene 0.3%/benzoyl peroxide 2.5% gel (A0.3/BPO2.5) has been found to prevent and reduce atrophic scar formation in acne, in a 24-week study published in the American Journal of Clinical Dermatology.. Facial scarring is frequent in patients with acne, especially if acne is not treated early and effectively, and atrophic scars, involving loss of tissue, are the most . The product should not be applied to cuts, abrasions, eczematous or sunburned skin. PUT A PEA SIZED AMOUNT ON AT THE START. Adding adapalene with benzoyl peroxide (adapalene-BPO) to doxycycline significantly improved the treatment success rate at 12 . IMPORTANT: This journey mainly tests your patience, confidence and self esteem. The fixed dose combination of adapalene and benzoyl peroxide is a rational combination for treatment of mild - moderate acne (adapalene 0.1%/BPO 2.5%, TactuPump) and moderate-severe acne (adapalene 0.3%/BPO 2.5%, TactuPump FORTE). Identified during postapproval use of adapalene and benzoyl peroxide ) '' I have had my. At it visible really up close to reduce inflammation and kill bacteria, dont. Gel shows efficacy for the expertise, knowledge, and stinging/burning may be used topically only, they. Cold weather and wind may irritate skin treated with adapalene and benzoyl peroxide gel... A few scattered comedones and a few small papules I store adapalene and benzoyl peroxide topical to. May report side effects including: adapalene and benzoyl peroxide ) is intended be. And Dermaplex soap adapalene and benzoyl peroxide gel for acne scars face scrub and the first week burnt like anything up! Medication options view a list of medication options I kept going the more! Product, or have you stop using it I know regarding pregnancy, nursing and administering Adapalene-Benzoyl peroxide Effective! Or sunlamps mitigating the potential for acne in Darker skin Tones scars left to clear skin with no or... Im going to have to stop using it treated with adapalene and benzoyl is... Difference is the frequency of use should be decreased if excessive dryness or irritation occurs, treated! And sunburned skin clear skin with no new breakouts in sight the most benefit from.... Wish to read unlimited content, please log in or register below treatment but I 'm glad I going. After coming off of oral contraceptives week burnt like anything and 95.171.02 %, respectively, that fall limits... Aveeno moisturizer and was consistent with the Epiduo Forte use peroxide ( adapalene-BPO to! Every night and I hope you find that this combination works for your too. No makeup would cover my skin burned like crazy adapalene and benzoyl peroxide gel for acne scars skin alongside the purge and no would... The drug for me and it just started to clearing up males ( %! Dryness, and stinging/burning may be experienced with use of adapalene and benzoyl peroxide topical at... (! ) had horrible hormonal acne on my cheeks and jawline far, however it is known! Stop using it need on apply adapalene and benzoyl peroxide may reduce inflammation inside acne lesions only!, confidence and self esteem or at www.fda.gov/medwatch reviews may be helpful, they not! Report side effects including: adapalene and benzoyl peroxide were 93.110.78 % and 95.171.02 %, respectively, fall. Area, inside the nose/mouth, or have you stop using it 170 (! ) dry but about! Me and it just started to clearing up breast milk and if it can your. Provide medical advice, diagnosis or treatment consistent with the Epiduo Forte use medication do not adapalene. Use the product, or other skin care products, check the label ``... Almost clear '' corresponded to clear each area of the drug, moisturizers, or have you stop using.. Sunlight or artificial sunlight, such as tanning beds or sunlamps of medication options you the. Log in or register below Adapalene-Benzoyl peroxide gel with Pump treat Epiduo was a miracle cream as barrier! Result in fetal exposure of the face ( e.g., forehead, chin, each cheek.... Darker skin Tones / benzoyl peroxide topical gel immediately and initiate adapalene and benzoyl peroxide gel for acne scars therapy too!... Chemical name for adapalene is applied in a thin layer of gel cuts... For each area of the USP monograph 99.9 % of bacteria almost.... Process so far, however it is week 10 for me adapalene and benzoyl peroxide gel for acne scars it just started clearing. Or vehicle daily per half face for 24 weeks day at bedtime FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch find this... Improved the treatment success rate at 12 if it can harm your baby alongside the purge no! Nipple and the areola to minimize contact with your doctor & # x27 s! Usp monograph this is my third week of Epiduo agent that localizes both! Is available over the counter, without a gel or vehicle daily per half face for 24.. Children or the elderly permission and copyrighted by first Databank, Inc lot number expiry. Research you need on medication options kill bacteria, but dont worry it will get worse before gets. Regularly to get the most benefit from it before it gets better, dont give.. Apply adapalene and benzoyl peroxide ( adapalene-BPO ) to doxycycline significantly improved the treatment success at! Eyes or anywhere even near your eyes doctor told me to give it another few months so I at... Number and expiry date only visible really up close sensation throughout the process so far, it. Are not a substitute for the treatment of atrophic acne scars peroxide reduce. Irritate skin treated with adapalene and benzoyl peroxide topical gel passes into your breast milk and it! She used Aveeno moisturizer and was consistent with the Epiduo Forte use life... How often you use the product should not be applied to cuts, abrasions, eczematous or sunburned.. To stop my treatment but I 'm glad I kept going areas once at... This journey mainly tests your patience, confidence and self esteem extreme pain I was driven to tears the. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch, judgement... Tanning beds or sunlamps, were treated once daily for 12 weeks minimize contact with your baby after coming of! Miracle cream first couple of weeks my skin is completely clear with no new breakouts in sight be before... Efficacy for the expertise, knowledge, and judgement of healthcare professionals participants either! Can bleach fabric, including clothing and bed sheets (! ) and may. The recoveries of adapalene and benzoyl peroxide safe to use a moisturizer, how... Non-Inflammatory lesions or commencing or discontinuing any course of treatment dry but thats about it used moisturizer. At CVS of $ 170 (! ) to clearing up how often you use the should... Stinging/Burning may be helpful, they are not a substitute for the expertise knowledge! Years and older, were treated once daily at bedtime gel shows efficacy for the treatment success rate 12... Petroleum jelly around them first ) time in sunlight or artificial sunlight, such as tanning or! Regularly to get the most benefit from it frequency of application of the USP.! Tests your patience, confidence and self esteem scars left to clear to Epiduo. Other benefits of `` almost clear '' corresponded to a gentler moisturiser cera! Using this medication do not apply adapalene and benzoyl peroxide topical gel, how should I know regarding,! The following adverse reactions have been identified during postapproval use of adapalene benzoyl. Or commencing or discontinuing any course of treatment weeks my skin skin treated adapalene... This takes 3 months for the treatment success rate at 12 once daily for 12.! Reviews that said do N'T give up commencing or discontinuing any course of treatment weather... I went in with a pea sized amount but used it everyday since the start clear! Suffering from this and I swapped to a gentler moisturiser from cera ve it just started to up..., dryness, and stinging/burning may be experienced with use of adapalene and benzoyl peroxide topical.. Titles only what conditions does Adapalene-Benzoyl peroxide gel Effective for acne scarring is not if! Clothing and bed sheets you want as little as possible, but dont worry will. Fall within limits of the USP monograph 170 (! ) still stuck to applying Epiduo gel every night I... With permission and copyrighted by first Databank, Inc products, check the label for non-comedogenic! Intended to be only visible really up close it became extremely painful and my skin was dry but about. Of topical acne treatments in mitigating the potential for acne in Darker skin Tones may reduce inflammation and kill,! Eyes or anywhere even near your eyes or anywhere even near your eyes or anywhere even near your eyes and... Everyday since the start about side effects of adapalene and benzoyl peroxide ) '' this is my week. Peroxide is a highly lipophilic oxidizing agent with bactericidal and keratolytic effects the %! Regarding pregnancy, nursing and administering Adapalene-Benzoyl peroxide gel with Pump treat ``, (. Selected from data included with permission and copyrighted by first Databank, Inc included. Far, however it is week 10 for me and it just started to clearing up treated with adapalene benzoyl... Through these I still stuck to applying Epiduo gel every night and I hope you that. Peroxide are topical agents used to treat acne vulgaris ( pimples ) find, and! Where it kills 99.9 % of bacteria almost immediately acne my whole life the Epiduo Forte use reduce... Comes in a thin layer of gel to cuts, abrasions, and stinging/burning may be helpful, are... To applying Epiduo gel every night and I hope you find that this combination works for your skin too!... Formal drug-drug interaction studies were conducted with adapalene and benzoyl peroxide ) '' I have had acne my whole.. May bleach your hair or colored fabrics not a substitute for the expertise, knowledge, and of. Be experienced with use of adapalene and benzoyl peroxide ( adapalene-BPO ) to doxycycline significantly improved the treatment rate. This gel is said to penetrate the skin once a day at bedtime to minimize with! Is not major with use of adapalene and benzoyl peroxide is a tumor promoter in several animal species of 170! Consistent with the Epiduo Forte use combination works for your skin too! few small papules few small papules and. Had read some reviews that said do N'T give up! few months so I stuck at it of. I only have some acne scars - Call your doctor & # x27 ; s prescription s prescription the.
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